Complete Genome Sequence of Strain JB001, a Member of Saccharibacteria Clade G6

The complexity and diversity of the microbial world was not fully understood until sequencing technology allowed us to study microbes without growing them in the lab. An important family of bacteria, Saccharibacteria (formerly called TM7), is one of the many bacteria of interest which were...

Scientific Pioneers

JCVI recognizes trailblazers in scientific history, particularly those who made advancements all while surpassing gender, ethnic, and other societal barriers, creating opportunity for the next generation of scientists. These historical figures not only helped advance our understanding of human...

Women’s History Month: Tu Youyou

Tu Youyou is a Chinese pharmaceutical chemist whose unique training in the classification of medical plants and their active ingredients resulted in a discovery that has led to the survival and improved health of millions of people. In 1967, at the height of the Vietnam War, malaria spread by...

SARS-CoV-2 Mutation Tracking

The Bacterial Viral Bioinformatic Resource Center (BV-BRC) is proud to introduce a new resource with the goal of providing live tracking of SARS-CoV-2 mutations. This real-time resource will provide regular reports focused on “Variants and Lineages of Concern” (VoCs/LoCs), and will serve as an early warning system for variants that are increasing in frequency in specific geographical locations.

JCVI Scientists and Interns Dramatically Trim Proteome Analysis Costs with New Lab-on-a-Filter Process

Through a happy accident and a keen mind, JCVI intern Rodrigo Eguez realized scientists might be able to pack their own filters rather than rely on those produced commercially at a significant cost savings. While playing around in the laboratory, he inadvertently disassembled a filter device...

Unique Antibody Pattern Discovered in COVID-19 ICU Patients May Be Key to Predicting Severe Outcomes

While news of promising COVID-19 vaccine trials is heartening, the fight to control infection rates and develop effective treatments will be an ongoing challenge for science for years to come. Gene Tan, PhD and his collaborators are working on identifying...

Synthetic Cell-Powered Lotion to Manage Type 1 Diabetes

Early last year we first talked about how researchers Yo Suzuki, PhD, and John Glass, PhD at JCVI set out to eliminate the need for type 1 diabetes (T1D) patients to receive insulin injections to manage blood glucose levels through a novel approach: developing a bacterial replacement for beta...

COVID-19 Further Complicating Flu Season

While the world is rightly focused on the ongoing COVID-19 pandemic, it’s important to know that influenza is always a significant public health burden, and the combination of the pandemic and flu season could converge to become a perfect storm of infectious diseases. Influenza causes 3 to...

Sara Josephine Baker

At the beginning of the 20th century, many people remained skeptical of both germ theory and preventative medicine, but pioneering physician Dr. Sara Josephine Baker fought to revolutionize public health and is credited with saving tens of thousands of lives. After studying chemistry and...

Gene Drives: New and Improved

As the science advances, policy-makers and regulators need to develop responses that reflect the latest developments and the diversity of approaches and applications.

Pink shoes and a lab jacket: Finding your way as a female scientist

Women in science tell high school girls they, too, can change the world

PEOPLE IN YOUR NEIGHBORHOOD: Jazz piano in La Jolla scientist Clyde Hutchison’s DNA

How AI can help us decode immunity

Artificial intelligence and machine learning will be the keys to unraveling how the human immune system prevents and controls disease

Construction of an Escherichia coli genome with fewer codons sets records

The biggest synthetic genome so far has been made, with a smaller set of amino-acid-encoding codons than usual — raising the prospect of encoding proteins that contain unnatural amino-acid residues.

Public Health is the Next Big Thing at UC San Diego

Researchers have swapped the genome of gut germ E. coli for an artificial one

By creating a new genome, scientists could create organisms tailored to produce desirable compounds

Genetically modified bacteria-killing viruses used on patient for first time