Comparative sequence analysis of S. pneumoniae TIGR 4 and a set of diverse S. pneumoniae strains.

August 16, 2006

The NIAID sponsored Pathogen Functional Genomics Resource Center (PFGRC) (NIAID contract N01-AI-15447) has funded a study on the evaluation of resequencing oligonucleotide array technology to detect genotypic variations in microorganisms. The PFGRC, in collaboration with Dr. Catherine McEllistrem, Division of Infectious Diseases, The University of Pittsburg, has evaluated Affymetrix CustomSeq Resequencing Oligonucleotide Array technology to detect genotypic variations in 85 S. pneumoniae isolates. A detailed description of the study may be found here and the data presentation may be found here, including a detailed, interactive SNP report providing comparative analyses between the TIGR 4 strain and any grouping of the S. pneumoniae isolates.