The Center for Structural Genomics of Infectious Diseases

The JCVI has been a consortium member of the Center for Structural Genomics of Infectious Disease (CSGID) sponsored by the National Institute for Allergy and Infectious Disease (NIAID) since 2007. The Center's mission is to solve the three-dimensional structure of proteins from pathogens in the NIAID Category A-C priority lists and organisms causing emerging and re-emerging infectious diseases. The targeted proteins are those with an important biological role or potential targets for vaccine and drug development.

The JCVI CSGID team has developed a high-throughput (HTP) cloning and protein expression pipeline to screen protein candidates for downstream scaled-up expression, protein purification and ultimately HTP structural determination. Clones yielding expressed, soluble protein are transferred to our consortium members who in turn apply state-of-the-art HTP structural biology technologies to experimentally determine the three-dimensional atomic structure. The three-dimensional structure of proteins will assist drug design and development by yielding direct insights into the target molecular mechanisms for interaction with other biological molecules or with synthetic compounds, in order to improve selectivity, specificity and optimize drug development in a rational way.

An individual or collaborative group of investigators interested in proposing a target for protein structure determination at the CSGID can submit a proposal to CSGID through www.csgid.org.

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Funding