Briefings in bioinformatics. 2002-09-01; 3.3: 236-45.

HMM-based databases in InterPro

Bateman A, Haft DH

PMID: 12230032


Protein family databases are an important resource for protein annotation and understanding protein evolution and function. In recent years hidden Markov models (HMMs) have become one of the key technologies used for detection of members of these families. This paper reviews the Pfam, TIGRFAMs and SMART databases that use the profile-HMMs provided by the HMMER package.