Publications

BMC genomics. 2005-12-08; 6.177.

Comparative analysis of programmed cell death pathways in filamentous fungi

Fedorova ND, Badger JH, Robson GD, Wortman JR, Nierman WC

PMID: 16336669

Abstract

Fungi can undergo autophagic- or apoptotic-type programmed cell death (PCD) on exposure to antifungal agents, developmental signals, and stress factors. Filamentous fungi can also exhibit a form of cell death called heterokaryon incompatibility (HI) triggered by fusion between two genetically incompatible individuals. With the availability of recently sequenced genomes of Aspergillus fumigatus and several related species, we were able to define putative components of fungi-specific death pathways and the ancestral core apoptotic machinery shared by all fungi and metazoa.

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