Hepatology (Baltimore, Md.). 2023-06-01; 77.6: 2073-2083.

Any alcohol use in NAFLD patients is associated with significant changes to the intestinal virome

Hsu CL, Lang S, Demir M, Fouts DE, Stärkel P, Schnabl B

PMID: 36631002


The prevalence of alcohol use disorder (AUD) and metabolic dysfunction-associated fatty liver disease (MAFLD) are increasing worldwide, leading to the increasing likelihood of both etiologies contributing to a patient's liver disease. However, the effects of modest alcohol use in NAFLD are controversial and more studies are needed. We compared the intestinal viromes of patients with AUD and NAFLD in order to evaluate the effect of alcohol consumption on the intestinal viromes of NAFLD patients by extracting virus-like particles and performing metagenomic sequencing.