Publications

Genome biology. 2004-01-01; 5.2: R34.

Orthologous gene-expression profiling in multi-species models: search for candidate genes

Grigoryev DN, Ma SF, Irizarry RA, Ye SQ, Quackenbush J, Garcia JG

PMID: 15128448

Abstract

Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biological processes of interest and selection of process-related candidate genes.

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