Entamoeba Resources

Entamoeba Protein Catalog

Advances in Parasitology Review   Entamoeba histolytica Nucleotide and Protein Sequences

Entamoeba histolytica, an intestinal parasite, is the causative agent of amoebiasis which is a diarrheal disease responsible for 40- 100,000 deaths primarily in developing countries. Since this protozoa has low infectious dose and may contaminate food and water supplies in the United States through dissemination, it has been categorized as a Category B priority pathogen as defined by the National Institute of Allergy and Infectious Diseases (NIAID).

Advances in Parasitology Review: Structure and Content of the Entamoeba histolytica Genome

A review of the Entamoeba histolytica genome entitled "Structure and Content of the Entamoeba histolytica Genome" by Clark et al., submitted to Advances in Parasitology. Email Graham Clark at: graham.clark@lshtm.ac.uk.

A number of tables, listed by section number (section 2.12 through section 10a), will be included with this publication as supplementary tables. These supplementary tables are linked in these pages to the annotated E. histolytica genes via their model mRNA (XM) or model protein (XP) accessions to TIGR's Annotation Display pages in TIGR's Entamoeba database.


Genome Annotation
The E. histolytica genome annotation was originally released in February 2005, published by Loftus et al. (Nature 433:2005) and is available at TIGR's Entamoeba histolytica Genome Project page. The genome is currently being re-annotated and a preliminary update of the re-annotation was released in July 2006 through TIGR's Pathema Entamoeba histolytica - reannotation Genome Page. This annotation is considered to be 'in progress' and the data on these pages is dynamic and will be updated over time. For updated Entamoeba annotation questions contact: enta@tigr.org.

The data presented in the "Advances in Parasitology Review" is based on the initial, February 2005 Entamoeba annotation. Some gene predictions included in the first annotation were later excluded from the July 2006 release after a first round of curation. The category "Excluded from the Reannotation" includes artifactual gene duplications due to misassembly, small ORFs below 300 bp with no matches to any database and disrupted ORFs that were predicted in retrotransposon/repeat regions.

Additional Entamoeba resources can also be found at the Entamoeba home page at the London School of Hygiene and Tropical Medicine.

The Entamoeba Resource Guide provides individual web pages for each section of the Supplementary Tables, with links to each section of the review listed below, plus additional Entamoeba-related resources.

Section 2. Genome Structure Proteins

• Synthetase and Modification Proteins (section 2.12)
• DNA Replication Initiation Proteins (section 2.13)
• Checkpoint Gene Homologues (section 2.13)
• Chromosome Segregation Saccharomyces cerevisiae Gene Homologues (section 2.13)
• Mitosis Saccharomyces cerevisiae Gene Homologues (section 2.13)
• Exit from Mitosis Saccharomyces cerevisiae Gene Homologues (section 2.13)
• Cytokinesis Saccharomyces cerevisiae Gene Homologues (section 2.13)
• CDKs and Cyclins (section 2.13)
• Cleavage and Polyadenylation Specificity Factors (CPSF) (section 2.14)

Section 3. Virulence Factor Proteins

• Gal/GalNAc Lectin Subunits (section 3.1)
• Cysteine Endopeptidase Families (section 3.2)

Section 4. Metabolism Enzymes

• Metabolism Enzymes (section 4.1)

Section 5. Cytoskeleton Proteins

• Microfilament Proteins (section 5.1)
• Actin and Actin-related Proteins (section 5.1)
• Tubulins and Microtubules (section 5.2)
• Molecular Motors (section 5.2)

Section 6. Vesicular Trafficking

• Vesicular Trafficking Genes (section 6.1)
• Entamoeba Sar and Arf Gene Annotation (section 6.2)
• Proteins Involved in Vesicle Formation: COPII, COPI, Clathrin (section 6.2a)
• SNARE Proteins (section 6.2b)

Section 7. Phosphatases

• Entamoeba Phosphatases (section 7)

Section 8. Mitosomal Proteins

• Mitosomal Proteins (section 8)

Section 10. Lateral Gene Transfer

• Lateral Gene Transfer (section 10)
• Updated BLAST Statistics for 96 Candidate LGT Cases (section 10)
• 68 Strongest LGT Cases (section 10a)

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Entamoeba histolytica Nucleotide and Protein Sequences

Entamoeba histolytica nucleotide and protein sequences can be retrieved from NCBI using taxonomy ID queries submitted against NCBI's Entrez nucleotide and protein databases. Results for these queries can be viewed by following the links provided. In addition, links to NCBI's Taxonomy Browser are available to provide navigation to genomic trace records.