, which accounts for between 40-100,000 deaths annually, is the causitive agent of amebiasis
. Amebiasis is predominantly seen in developing countries where a high prevalence of infection is due to fecal contamination of food and water supply. more >>
The current version of E. histolytica
on Pathema is the reannotation of the genome. All genes from the original annotation have been mapped to the new annotation.
Available Pathema-Entamoeba Genomes
Click on the organism of interest for a list of the genomes available.
Entamoeba Strain & DNA Availability
Get information on how to obtain Entamoeba
bacteria, DNA, antibodies and antigens through the NIAID funded BEI Resources
and the ATCC
Genome Annotation at JCVI
resource provides updated gene model and functional curation following standardized protocols for all publicly available Entamoeba
Community members are encouraged to participate in our annotation effort by registering and submitting updates from individual gene pages. Sign up using the link below to register for community annotation.
Entamoeba Gene Search
Highlighted Gene Tools & Lists
resource offers several whole-genome and multi-genome comparative tools to help identify regions and proteins of interest. Homologous protein results are pre-computed using blastp and can be viewed using a number of our homology tools under the Comparative Tools menu. Sequence alignment of specific molecules can be obtained using MUMmer.
Protein ortholog clusters
Precomputed protein ortholog clusters (based on the blastp results) support a number of additional gene and genome-level reports and graphical displays, including those listed below. Each protein cluster is also displayed on a cluster report page like this one
resource provides pre-computed blastp results for each protein against every other protein in the database. Detailed results can be obtained via the individual gene pages' Protein vs. All Alignment link. ClustalW and BER alignments are also acccesible from this gene page tool.
Functional genomics attempts to make use of the vast wealth of data produced by genomic projects to describe gene and protein functions and interactions. Functional genomics focuses on dynamic aspects such as gene transcription, translation, and protein-protein interactions, as opposed to the static aspects of the genomic information such as DNA sequence or structures. Below we list the current tools available for functional genomics studies of Entamoeba.
Pathways are manually drawn pathway maps representing the molecular interaction and reaction networks for metabolism, other cellular processes, and human diseases.
SRI Pathway Tools
The Pathway Tools software is a bioinformatics software system for pathway analysis of genomes, and for creating Pathway/Genome Databases (PGDBs). A PGDB, such as EcoCyc
, is a bioinformatics DB that integrates genomic data with detailed functional annotations of the genome, such as descriptions of metabolic and signaling pathways. Pathway Tools was developed by Peter D. Karp
and coworkers at the Bioinformatics Research Group
at SRI International.
is a relational database describing the predicted cytoplasmic membrane transport protein complement for organisms whose complete genome sequence are available. For each organism, its complete membrane transport complement was identified, classified into protein families according to the TC classification system, and functional predictions are provided. Complete lists of the transporters from each organism are accessible from the pull down menus on this page.
Entamoeba Protein Catalog
The Entamoeba Protein Catalog
provides individual lists of Entamoeba
proteins including structures, metabolism enzymes, cytoskeleton proteins and vesicular trafficking.
Genome Structure Proteins
Lateral Gene Transfer
Here the top used tools and searches
in Pathema are listed. In the future users will be able to put their own customized favorite tools in this box.
Entamoeba Gene Search
Entamoeba Organism Search